Expanding our R&D potential


June 5, 2020

We have co-authored 4 new papers as a result of a cooperation with multiple research institutes: 1)  Opposite regulation of piRNAs, rRNAs, and miRNAs in the blood after subarachnoid hemorrhage - this report describes alterations in sRNAs abundance levels in response to IA rupture in humans. The obtained results indicate novel mechanisms that may constitute another level of control of the inflammatory response. Read the full article here. 2)  Underestimated Aspect of Mucopolysaccharidosis Pathogenesis: Global Changes in Cellular Processes Revealed by Transcriptomic Studies – the results of this study may shed a new light on the mechanisms of genetic diseases, indicating how a single mutation can result in complex pathomechanism, due to perturbations in the network of cellular reactions. Read the abstract here. 3)  Inflammatory Responses Induced by the Rupture of Intracranial Aneurysms Are Modulated by miRNAs - these results may aid in the elucidation of the molecular mechanisms that orchestrate the inflammatory response to IA rupture. Read the abstract here. 4)  Genetic Signature of Acute Lymphoblastic Leukemia and Netherton Syndrome Co-incidence—First Report in the Literature – to our knowledge, we present the first case report of ALL in a patient with NS. WES allowed for the detection of two novel germline mutations and initial qualification of leukemia diagnosed in our patient as Ph-like ALL. Moreover, detection of JAK2 gene mutation may offer an opportunity to personalize the treatment. A specific signature of rare germline variants and somatic mutations can be proposed as a predisposing factor to the coexistence of ALL and NS. Read the full article here.
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