Implementation of YAML-based models for PGx and PRS genomic analysis
Application of long-read sequencing to improve genotyping of complex pharmacogenetic regions Pharmacogenomics (PGx) is a critical field in personalized medicine, focusing on how an individual’s genetic makeup influences their response to drugs. By analyzing genetic variants that affect drug metabolism, efficacy, and toxicity, PGx can guide tailored treatments, ensuring optimal drug selection and dosing. This […]
From Phenotype to Clinical Practice: Implementing Pharmacogenetic (PGx) Recommendations
Pharmacogenomics, the study of how genes affect a person’s response to drugs, is crucial in the realm of personalized medicine. Pharmacogenes, the genes encoding factors directly involved in drug actions, can be broadly classified into two functional groups: metabolic enzymes and transporters/receptors. Enzyme pharmacogenes are responsible for converting substrates, such as drugs, into smaller molecules, […]